There has been enormous debate regarding the possibility of a link between childhood vaccinations and the subsequent development of autism. This has in recent times become a major public health issue with vaccine preventable diseases increasing in the community due to the fear of a 'link' between vaccinations and autism. We performed a meta-analysis to summarise available evidence from case-control and cohort studies on this topic (MEDLINE, PubMed, EMBASE, Google Scholar up to April, 2014). Eligible studies assessed the relationship between vaccine administration and the subsequent development of autism or autism spectrum disorders (ASD). Two reviewers extracted data on study characteristics, methods, and outcomes. Disagreement was resolved by consensus with another author. Five cohort studies involving 1,256,407 children, and five case-control studies involving 9,920 children were included in this analysis. The cohort data revealed no relationship between vaccination and autism (OR: 0.99; 95% CI: 0.92 to 1.06) or ASD (OR: 0.91; 95% CI: 0.68 to 1.20), nor was there a relationship between autism and MMR (OR: 0.84; 95% CI: 0.70 to 1.01), or thimerosal (OR: 1.00; 95% CI: 0.77 to 1.31), or mercury (Hg) (OR: 1.00; 95% CI: 0.93 to 1.07). Similarly the case-control data found no evidence for increased risk of developing autism or ASD following MMR, Hg, or thimerosal exposure when grouped by condition (OR: 0.90, 95% CI: 0.83 to 0.98; p=0.02) or grouped by exposure type (OR: 0.85, 95% CI: 0.76 to 0.95; p=0.01). Findings of this meta-analysis suggest that vaccinations are not associated with the development of autism or autism spectrum disorder. Furthermore, the components of the vaccines (thimerosal or mercury) or multiple vaccines (MMR) are not associated with the development of autism or autism spectrum disorder.
Keywords: Autism; Autism spectrum disorder; Immunisation; Mercury; Thimerosal; Vaccination; Vaccine.
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Turville C, Golden I. Turville C, et al. Vaccine. 2015 Oct 13;33(42):5494-5496. doi: 10.1016/j.vaccine.2015.02.002. Epub 2015 Feb 24. Vaccine. 2015. PMID: 25724821 No abstract available.
Eslick GD. Eslick GD. Vaccine. 2015 Oct 13;33(42):5497. doi: 10.1016/j.vaccine.2015.05.100. Epub 2015 Jul 18. Vaccine. 2015. PMID: 26192352 No abstract available.
Hawkes D, Dunlop RA, Benhamu J. Hawkes D, et al. Vaccine. 2016 Jun 14;34(28):3223-4. doi: 10.1016/j.vaccine.2015.12.031. Vaccine. 2016. PMID: 27288998 No abstract available.
Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. Uno Y, et al. Vaccine. 2015 May 15;33(21):2511-6. doi: 10.1016/j.vaccine.2014.12.036. Epub 2015 Jan 3. Vaccine. 2015. PMID: 25562790
Geier DA, Geier MR. Geier DA, et al. Med Sci Monit. 2004 Mar;10(3):PI33-9. Epub 2004 Mar 1. Med Sci Monit. 2004. PMID: 14976450
Scahill L, Bearss K. Scahill L, et al. J Child Adolesc Psychiatr Nurs. 2009 Feb;22(1):51-3. doi: 10.1111/j.1744-6171.2008.00152.x. J Child Adolesc Psychiatr Nurs. 2009. PMID: 19200293 Review. No abstract available.
DeStefano F. DeStefano F. Clin Pharmacol Ther. 2007 Dec;82(6):756-9. doi: 10.1038/sj.clpt.6100407. Epub 2007 Oct 10. Clin Pharmacol Ther. 2007. PMID: 17928818 Review.
Parker SK, Schwartz B, Todd J, Pickering LK. Parker SK, et al. Pediatrics. 2004 Sep;114(3):793-804. doi: 10.1542/peds.2004-0434. Pediatrics. 2004. PMID: 15342856 Review.
Gulle BT, Yassibas U, Sarigedik E. Gulle BT, et al. J Autism Dev Disord. 2024 Aug 8. doi: 10.1007/s10803-024-06508-x. Online ahead of print. J Autism Dev Disord. 2024. PMID: 39115743
Soriolo N, Benoni R, Dalla Valle D, Zunino F, Olivieri A, Campagna I, Tardivo S, Augusta Gonella L, Russo F, Tonon M, Da Re F, Moretti U, Zanoni G, Moretti F. Soriolo N, et al. Prev Med Rep. 2024 Mar 29;41:102711. doi: 10.1016/j.pmedr.2024.102711. eCollection 2024 May. Prev Med Rep. 2024. PMID: 38606113 Free PMC article.
Baia-da-Silva DC, Mendes PFS, Silva DCBD, Chemelo VS, Bittencourt LO, Padilha PM, Oriá RB, Aschner M, Lima RR. Baia-da-Silva DC, et al. Heliyon. 2024 Mar 19;10(7):e27526. doi: 10.1016/j.heliyon.2024.e27526. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38586377 Free PMC article.
Melo Júnior EB, Almeida PD, Pereira BM, Borges PTM, Gir E, Araújo TME. Melo Júnior EB, et al. Rev Bras Enferm. 2023 Nov 27;76(5):e20220707. doi: 10.1590/0034-7167-2022-0707. eCollection 2023. Rev Bras Enferm. 2023. PMID: 38018617 Free PMC article. Review.
László K, Vörös D, Correia P, Fazekas CL, Török B, Plangár I, Zelena D. László K, et al. Biomedicines. 2023 Sep 22;11(10):2603. doi: 10.3390/biomedicines11102603. Biomedicines. 2023. PMID: 37892977 Free PMC article. Review.